Research Studies

Formulated for Heart Health

Title

Tested by Tradition. Validated by Research.

Ubiquinol

Traditionally used to support energy production and cardiovascular health, especially helpful for maintaining CoQ10 levels while aging. View Research >

Several studies support Ubiquinol’s role in enhancing energy production and cardiovascular health, especially as we age. Ubiquinol, the active form of Coenzyme Q10 (CoQ10), is essential for cellular energy as it shuttles electrons within the mitochondria, the “powerhouse” of cells, where it helps generate ATP, the main energy source for cellular function. This is particularly vital for organs with high energy demands, like the heart.

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

Coenzyme Q10 Supplementation in Aging and Disease

As we age, natural CoQ10 levels decline, leading to reduced energy availability and increased oxidative stress, which can impact heart health. Research shows that CoQ10 supplementation—particularly with Ubiquinol due to its higher bioavailability—can counteract these declines. A study on older adults revealed that long-term CoQ10 supplementation improved heart function and reduced cardiovascular mortality

The Use of Coenzyme Q10 in Cardiovascular Diseases

Magnesium Orotate + Aspartate

Known for its role in managing inflammation, promoting stress resilience, and supporting overall cardiovascular health. View Research >

Research highlights that magnesium orotate and aspartate have significant roles in supporting cardiovascular health, inflammation management, and stress resilience. Magnesium, in its various forms, acts as a cofactor in over 300 enzymatic reactions, including those that impact cardiovascular functions like heart rhythm regulation, blood vessel relaxation, and blood pressure control. Studies emphasize that magnesium’s anti-inflammatory properties help reduce chronic inflammation, a contributor to cardiovascular disease, making it valuable for individuals with heart conditions.

Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

Magnesium, in general, plays an essential role in controlling inflammation and supporting stress resilience. A deficiency in magnesium is linked to increased inflammation and oxidative stress, factors that elevate cardiovascular risk. Magnesium supplementation can help manage these risks, which is especially relevant in the context of heart disease:

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease

Kyolic Garlic

Traditionally used to help regulate cholesterol and support cardiovascular wellness. View Research >

Studies on Kyolic aged garlic extract (AGE) highlight its role in supporting cardiovascular health, particularly by lowering blood pressure and reducing arterial stiffness. In hypertensive individuals, AGE has demonstrated similar efficacy to standard blood pressure medications, significantly reducing both systolic and diastolic pressure. The extract’s benefits are linked to its influence on nitric oxide production and its prebiotic properties, which help improve gut microbiota diversity—both of which contribute to cardiovascular health.

The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: The GarGIC Trial

Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis

Vitamin K2

Supports calcium regulation, aiding bone health and cardiovascular function. View Research >

Vitamin K2 plays a critical role in both bone and cardiovascular health by regulating calcium distribution within the body. It supports the activation of key proteins like matrix Gla protein (MGP) and osteocalcin, which are essential for calcium binding and transport. This process prevents excess calcium from depositing in blood vessels, which can lead to vascular calcification, while also directing calcium to bones, enhancing bone mineral density and reducing osteoporosis risk

The Dual Role of Vitamin K2 in “Bone-Vascular Crosstalk”: Opposite Effects on Bone Loss and Vascular Calcification

The Medical Benefits of Vitamin K2 on Calcium-Related Disorders

Studies have shown that adequate levels of Vitamin K2 contribute to improved cardiovascular outcomes by minimizing arterial stiffness and preventing calcium buildup in arteries, known as the "calcium paradox." This beneficial effect on vascular health is particularly relevant in ageing populations, where the risk of both osteoporosis and cardiovascular disease is higher

The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review

Curcumin

Recognized for its anti-inflammatory and antioxidant properties, traditionally used to support general wellness. View Research >

Curcumin is widely recognized for its powerful anti-inflammatory and antioxidant properties, which are particularly valuable in managing chronic inflammation and oxidative stress. Studies show that curcumin targets key inflammatory pathways, reducing pro-inflammatory markers like cytokines IL-1β, IL-6, and TNF-α. This modulation of inflammation is especially beneficial for conditions related to chronic disease management, including arthritis, cardiovascular health, and metabolic syndrome.

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

Curcumin also exhibits potent antioxidant effects by scavenging free radicals and supporting cellular defense mechanisms, thereby helping reduce oxidative stress, which is a contributor to aging and CVD, amongst other chronic diseases.

Curcumin: A Review of Its Effects on Human Health

Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia1

Hawthorn Berry

Supports liver health and may help with inflammation management through antioxidant production. View Research >

Hawthorn Berry has been traditionally used for cardiovascular health, and modern research supports its role in maintaining blood pressure, improving circulation, and supporting overall heart function. Studies indicate that hawthorn’s beneficial effects stem from its high levels of antioxidants, particularly flavonoids, which help reduce oxidative stress and support blood vessel health. These compounds can enhance endothelial function (the cells lining blood vessels), which is crucial for maintaining vascular flexibility and managing blood pressure effectively.

Roles and Mechanisms of Hawthorn and Its Extracts on Atherosclerosis: A Review

One study found that hawthorn extract could lower blood pressure by promoting nitric oxide production, which relaxes blood vessels, and by reducing inflammatory markers involved in cardiovascular stress. This vasodilatory effect helps improve circulation, making hawthorn particularly beneficial for people with hypertension and other circulatory issues. Additionally, hawthorn has shown potential in lipid regulation, further supporting cardiovascular health by balancing cholesterol levels.

Food Applications and Potential Health Benefits of Hawthorn

N-Acetylcysteine (NAC)

Traditionally used to help regulate cholesterol and support cardiovascular wellness. View Research >

N-Acetylcysteine (NAC) is well-recognized for its antioxidant and anti-inflammatory benefits, particularly for liver health. As a precursor to glutathione, one of the body’s primary antioxidants, NAC helps to reduce oxidative stress and inflammation markers, supporting overall cellular health. Research shows that NAC’s action as an antioxidant assists in managing oxidative stress linked to liver diseases and other conditions characterized by high levels of inflammation. This capability is due to its role in restoring glutathione levels, which help neutralize harmful free radicals and maintain liver function under stress.

N-Acetylcysteine (NAC): Impacts on Human Health

Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine

Additionally, NAC has demonstrated potential in reducing pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, which are key contributors to inflammation. This anti-inflammatory effect is particularly relevant for managing liver health and conditions that involve high oxidative stress levels, making NAC beneficial in both clinical and supplemental contexts.

N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells

Ashwagandha

Traditionally known for aiding in mental and physical stress resilience. View Research >

Ashwagandha, or Withania somnifera, is traditionally known for its adaptogenic properties, helping the body manage both mental and physical stress. Research shows that Ashwagandha can improve resilience to stress by reducing levels of cortisol, the body's primary stress hormone. Studies indicate that regular Ashwagandha supplementation can lower stress and anxiety scores, while also supporting physical performance and reducing mental fatigue, making it highly beneficial for overall stress resilience and mental well-being.

One review found that Ashwagandha’s active compounds, particularly withanolides, help reduce inflammation and support the nervous system, contributing to its anti-stress effects. Additionally, it has neuroprotective properties that improve cognitive function, potentially aiding in mood balance and sleep quality, which are often impacted by chronic stress.

Ashwagandha’s Multifaceted Effects on Human Health: Impact on Vascular Endothelium, Inflammation, Lipid Metabolism, and Cardiovascular Outcomes—A Review

Effects of Ashwagandha on Cortisol and Stress

Terminalia Arjuna

Traditionally used to support cardiovascular strength and assists in maintaining healthy blood pressure. View Research >

Studies on Terminalia arjuna (T. arjuna) support its traditional use for cardiovascular health, particularly in strengthening the heart and managing blood pressure. T. arjuna’s bark contains bioactive compounds like flavonoids and tannins, which contribute to its cardioprotective properties. Research shows that T. arjuna can help regulate blood pressure through its hypotensive effects, achieved by enhancing vasodilation and reducing peripheral resistance in blood vessels

Terminalia arjuna, a Cardioprotective Herbal Medicine–Relevancy in the Modern Era of Pharmaceuticals and Green Nanomedicine.

One study found that T. arjuna reduces oxidative stress and supports endogenous antioxidants, which is beneficial for heart tissue, particularly in conditions like ischemia (restricted blood flow) or myocardial injury. This effect is primarily due to T. arjuna’s ability to reduce reactive oxygen species (ROS) and lipid peroxidation, protecting heart cells from damage.

Revisiting Terminalia arjuna –An Ancient Cardiovascular Drug

Selenium

An antioxidant that supports inflammation management and immune health. View Research >

Selenium is a powerful antioxidant and essential micronutrient, particularly known for its role in reducing inflammation and supporting immune health. Studies highlight that selenium functions primarily through its incorporation into selenoproteins, which are crucial for protecting cells against oxidative damage and managing immune responses. These antioxidant effects help mitigate oxidative stress, which can reduce inflammation and support cellular resilience, particularly in the immune system.

Research also shows selenium’s impact on immune cell activation and regulation, enhancing both innate and adaptive immunity, which is beneficial in managing various infections and potentially reducing the risk of chronic inflammation

The Immunomodulatory Effects of Selenium: A Journey from the Environment to the Human Immune System

Furthermore, selenium’s influence on redox homeostasis is key to maintaining balance in inflammatory and immune pathways, particularly important in aging populations where oxidative stress is higher

Selenium: An Antioxidant with a Critical Role in Anti-Aging

L-Citrulline

Known for its role in promoting healthy blood flow and cardiovascular wellness. View Research >

Research supports that L-Citrulline promotes cardiovascular health by enhancing blood flow and improving endothelial function. This amino acid, through conversion to L-arginine, increases nitric oxide (NO) production—a key vasodilator that helps relax blood vessels and reduce blood pressure. Studies have shown that L-Citrulline supplementation effectively improves arterial function and blood flow, especially in populations with hypertension, such as postmenopausal women. Additionally, it has been found to improve oxygenation in muscle tissue during exercise, which can enhance physical endurance and resilience during activities

l-Citrulline Supplementation: Impact on Cardiometabolic Health

Effects of L-Citrulline Supplementation on Endothelial Function and Blood Pressure in Hypertensive Postmenopausal Women

L-Citrulline Supplementation Improves Arterial Blood Flow and Muscle Oxygenation during Handgrip Exercise in Hypertensive Postmenopausal Women

Taurine

Helps maintain electrolyte balance and supports general cardiovascular health. View Research >

Research supports taurine's beneficial role in cardiovascular health, particularly through its functions in electrolyte balance and anti-inflammatory properties. Taurine acts as a modulator for ion movement and osmoregulation, which helps maintain proper electrolyte balance—vital for heart health. Studies show it also assists in blood pressure regulation and protects against coronary artery disease by reducing inflammation and oxidative stress within the cardiovascular system, partly through inhibition of the renin-angiotensin system.

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis

Experience the Benefits

Join the community for exclusive heart health related insights

Title

Disclaimer: StrongHeart is a dietary supplement designed to support heart health. This product is not intended to diagnose, treat, cure, or prevent any disease. The statements on this website have not been evaluated by the Therapeutic Goods Administration (TGA) or the U.S. Food and Drug Administration (FDA). Please consult with your healthcare professional before using this product, especially if you are taking medications or have a medical condition. StrongHeart is available for purchase in Australia and the United States.

Privacy Policy | Terms of Services